Wound healing/plastic surgery
Morphologic study of three collagen materials for body wall repair1
Emily E. Soiderer D.V.M.*, Gary C. Lantz D.V.M., , *, Evelyn A. Kazacos D.V.M., Ph.D., Jason P. Hodde M.S. and Ryan E. Wiegand M.S.§
* Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, Indiana, USA
Department of Veterinary Pathobiology, Purdue University, West Lafayette, Indiana 47907, USA
Cook Biotech Incorporated, West Lafayette, Indiana, USA
§ Department of Statistics, Purdue University, West Lafayette, Indiana 47907, USA
Received 16 July 2003. Available online 26 April 2004.
Abstract
Background
The search for ideal prostheses for body wall repair continues. Synthetic materials such as polypropylene mesh (PPM) are associated with healing complications. A porcine-derived collagen-based material (CBM), small intestinal submucosa (SIS), has been studied for body wall repair. Renal capsule matrix (RCM) and urinary bladder submucosa (UBS) are CBMs not previously evaluated in this application. This is the first implant study using RCM.
Materials and methods
Full-thickness muscle/fascia ventral abdominal wall defects were repaired with SIS, RCM, UBS, and PPM in rats with omentum and omentectomy. A random complete block design was used to allot implant type to each of 96 rats. Healing was evaluated at 4 and 8 weeks. Adhesion tenacity and surface area were scored. Implant site dimensions were measured at implantation and necropsy. Inflammation, vascularization, and fibrosis were histopathologically scored. Data were compared by analysis of variance (P